Mixed large cell neuroendocrine carcinoma and high grade serous carcinoma of the ovary: a histopathological case report

Large cell neuroendocrine carcinoma (LCNEC) of the ovary is an uncommon gynaecological malignancy with aggressive clinical course.1 In most instances ovarian LCNEC associated a surface epithelial tumour or mature cystic teratoma.2 Mixed and high grade serous (HGSC) exceedingly rare subentity, only handful cases identified in literature.1 We report case 56-year-old female who presented four week history postmenopausal bleeding mild abdominal distension. Investigations revealed 16 cm solid left mass no evidence extra-pelvic malignancy. The patient underwent total hysterectomy, bilateral salpingo-oopherectomy, pelvic lymph node biopsy, peritoneal biopsy omentectomy. Microscopic examination demonstrated composite (98%) HGSC (2%) ovary. endometrium showed focal involvement by HGSC. Serous tubal intraepithelial (STIC) right fallopian tube invasive extending into adherent was identified, keeping tubo-ovarian origin. received adjuvant chemotherapy. Comparative molecular analysis different components via immunohistochemistry microsatellite instability testing on microdissected paraffin embedded tissue ongoing. References 1. Burkeen G, Chauhan A, Agrawal R, et al. Gynecologic large carcinoma: review. Rare Tumors 2020; 12: 2036361320968401. 2. Georgescu T-A, Bohiltea RE, Munteanu O, Emerging therapeutic concepts latest diagnostic advancements regarding tumors gynecologic tract. Medicina 2021; 57: 1338.